Sildenafil (Ingredient)
^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra!
| Aspect | Prescription Sildenafil | OTC Sildenafil |
|---|---|---|
| Availability | Only through healthcare provider | Directly in stores or online |
| Dosage Options | Typically higher, e.g., 100 mg | Usually 25-50 mg, lower doses |
| Medical Oversight | Required for safe use | Not required, but caution advised |
| Potential Risks | Higher if misused | Lower, but side effects still possible |
^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction". "Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived sildenafil 100 mg cost from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture". "A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to go generic in 2017 according to Pfizer agreement". Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half".
| Precaution / Contraindication | Explanation | Alternative Actions or Notes |
|---|---|---|
| Use with nitrates | Dangerous, can cause severe hypotension | Seek medical advice |
| Heart conditions | May worsen certain conditions | Consult doctor before use |
| Alcohol consumption | Can increase side effects or reduce efficacy | Limit alcohol intake |
| Interactions with other meds | Potential for adverse interactions | Review all medications with a healthcare provider |
Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020.
- OTC Sildenafil products may contain counterfeit or substandard ingredients.
- Many OTC Sildenafil products are marketed as quick fixes for erectile issues.
- The availability of OTC Sildenafil has increased with online shopping.
- OTC Sildenafil use outside medical supervision can be dangerous.
- Some OTC formulations include herbal or natural ingredients with Sildenafil.
- The safety of OTC Sildenafil depends heavily on manufacturing practices.
- Potential side effects include headaches, dizziness, and blood pressure changes.
- OTC Sildenafil should be avoided by those with certain health conditions.
- Always read labels carefully before purchasing OTC Sildenafil.
- OTC Sildenafil can interact with medications like nitrates, causing hypotension.
- Seek medical advice before starting OTC Sildenafil treatments.
^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide".
What happens if I overdose?
^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. ^ "Hidden Risks of Erectile Dysfunction sildenafil tables 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R.
Warnings for other groups
Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011. "Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says".
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Kamagra | 100mg | 12 Pills | 55.64€ 52.99€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ |
^ "Global sildenafil film tablet illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S.
12.2 Pharmacodynamics
^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today". Archived from the original on 25 November 2018. Archived from the original on 12 February 2022. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S.
Health News
"Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing sexual dysfunction induced by antidepressant medication". The Cochrane Database of Systematic Reviews (5) CD003382. Archived from the original on 10 October 2020. "Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review".
Vybrique Oral Film
Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options". "Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis". "Interventions for preventing high altitude illness: Part 1. Archived from the original on 10 June 2017. Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012.
- The legality of OTC Sildenafil varies by jurisdiction; some countries ban sales.
- Many OTC Sildenafil products are marketed as "natural" or "herbal" remedies.
- Consumers should be wary of false advertising claims on OTC Sildenafil labels.
- Some OTC Sildenafil products come in online "complimentary" health packages.
- OTC Sildenafil may be marketed as an alternative when prescription is difficult.
- There is a rise in OTC Sildenafil products targeting men over 40.
- OTC Sildenafil popularity has increased due to ease of availability online.
- Prices for OTC Sildenafil vary widely depending on branding and source.
- Some OTC Sildenafil products are capsules, powders, or dissolvable tablets.
- OTC Sildenafil use might mask underlying health conditions needing medical attention.
- The safety profile of OTC Sildenafil is less studied than prescription versions.
^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016.
- Often, OTC Sildenafil is marketed with false claims of "all natural" ingredients.
- OTC drugs containing Sildenafil are sometimes used as party drugs for ED enhancement.
- Many countries have strict regulations banning OTC Sildenafil sales.
- OTC Sildenafil can trigger dangerous hypotension in some users.
- Users should avoid OTC Sildenafil if they are taking medications affecting blood flow.
- OTC Sildenafil’s unregulated status increases the risk of adverse effects.
- Proper dosage information is essential but often missing on OTC products.
- OTC Sildenafil should be purchased from reputable sources to ensure safety.
- Doctors warn against using OTC Sildenafil without proper diagnosis.
- Long-term health effects of OTC Sildenafil are still under study.
- OTC Sildenafil misuse can lead to serious health emergencies.
{{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v.
We’re here to help!
"Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006). "The rise of Viagra among British illicit drug users: 5-year survey data". "Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013.
Viagra Brand
"Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. "Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra ..
Super P Force
on the Field". Archived from the original on 5 March 2016. "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". Archived from the original on 4 March 2016. Pfizer Canada Inc., 2012 SCC 60 at par.
- OTC Sildenafil is frequently involved in drug misuse and abuse cases.
- Many OTC Sildenafil supplements are labeled as dietary aids or supplements.
- Consumers should educate themselves about potential risks before using OTC Sildenafil.
- OTC Sildenafil products are sometimes flavored or disguised to appeal to consumers.
- Purchasing OTC Sildenafil online can expose users to scams and frauds.
- The legality of OTC Sildenafil depends on local drug laws and regulations.
- OTC Sildenafil can cause allergic reactions in sensitive individuals.
- OTC Sildenafil may interact negatively with herbal medicines.
- The increase in OTC Sildenafil options raises concern about safety standards.
- The best safeguard is to consult healthcare providers before OTC use.
- OTC Sildenafil should not be used if experiencing chest pain or other health issues.
"Supreme Court ruling could lead to cheaper versions of Viagra". Archived from the original on 10 March 2013. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced". Archived from the original on 18 September 2013. ^ "Pfizer Canada drops Viagra price after generic versions get Supreme Court green light". Archived from the original on 30 November 2012. Archived from the original on 27 December 2013. "In rare move, Pfizer asks Supreme Court to reconsider ruling that killed Viagra patent".
| Parameter | Description | Typical Values | Notes |
|---|---|---|---|
| Absorption Time | Time to reach peak plasma concentration | 30-120 minutes | Varies with formulation |
| Half-life | Duration of drug's effect | 4-6 hours | Clearance processed mainly by liver |
| Bioavailability | Percentage of active drug absorbed into bloodstream | ~40-50% | Affected by food intake |
Archived from the original on 5 February 2013. "The Supreme Court of Canada holds Pfizer's Viagra patent invalid". Archived from the original on 20 May 2013. ^ "Actavis Launches Generic Viagra in Europe as Patents Expire". Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". Archived from the original on 23 April 2011. ^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013. Archived from the original on 22 August 2009. Archived from the original on 25 June 2007.
7.3 Amlodipine
^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016. "Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". ^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". "Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension".
Viagra Soft Tabs
"Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association". Journal of the American College of Cardiology. ^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses".
Super Kamagra
Archived from the original on 12 July 2018. "Young men add Viagra to their drug arsenal". Archived from the original on 4 September 2014. "Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Viagra from the pharmacist: insight from reclassification in New Zealand". Archived from the original on 17 May 2021. ^ "Generic Viagra developers queue up, but may have to wait". Archived from the original on 28 December 2021.
