Investigating Sildenafil as a Potential Treatment for PE

Conditions related to the shape of your penis. If you have conditions related to the shape of your penis, such as Peyronie’s disease, tell your doctor. These conditions may increase your risk of severe priapism* during sildenafil treatment. If you experience an erection lasting longer than 4 hours, call 911 or your local emergency number immediately. If you take nitrates for any reason. Taking sildenafil with drugs containing nitrates is contraindicated.

• Premature ejaculation affects about 30% of men.
• Psychological factors often contribute to PE.
• Behavioral therapies can help manage PE.
• Topical anesthetics are alternative treatments for PE.
• SSRI antidepressants are commonly prescribed for PE.
• Combining sildenafil with PE drugs requires care.
• Lifestyle changes like exercise may improve PE.
• Stress and anxiety can trigger premature ejaculation.
• Delay techniques include the stop-start method.
• Medical treatments should be personalized for each patient.
• Education about sexual response can reduce PE.

(A contraindication is a factor or condition that could prevent your doctor from prescribing a drug due to risk of harm.) This is due to sildenafil’s potential to cause severe low blood pressure.

* Examples of nitrates include nitroglycerin (Nitrolingual), isosorbide (Isordil), nitroprusside (Nitropress). If you take any of these drugs or any other nitrates, be sure to tell your doctor before starting sildenafil treatment. Sildenafil is contraindicated if you take a GC stimulator, including riociguat (Adempas). This is because these drugs may cause severe low blood pressure. Be sure to tell your doctor sildenafil 45 mg chewable tablets if you take this drug. They’ll likely recommend you do not take riociguat with sildenafil. * For more details about this side effect, see the “Sildenafil: Serious side effects” section above. It’s unknown whether sildenafil is safe to take while pregnant or breastfeeding.

• Sildenafil enhances blood flow but doesn't directly delay ejaculation.
• PE is often linked with heightened genital sensitivity.
• Timed use of sildenafil may improve sexual confidence.
• Medication dose should be carefully managed.
• PDE5 inhibitors may have a role in PE enhancement.
• Regular sexual activity can help reduce PE symptoms.
• Psycho-sexual therapy addresses underlying issues.
• Identifying triggers can help manage PE episodes.
• Drugs are part of a comprehensive PE management plan.
• Pharmacotherapy may require adjustment over time.
• Always follow medical advice regarding medication use.

Animal studies* did not show harm to the fetus when the drug was exposed to pregnant animals.

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Certain factors can increase your risk of developing NAION during sildenafil treatment. These include previous eye conditions or coronary artery disease. They also include being age 50 years or older or smoking. Before starting sildenafil treatment, be sure to tell your doctor if you have any of these factors. They’ll help determine if the drug is right for you. However, keep in mind that animal studies don’t always reflect what will happen in humans. If you’re pregnant or can become pregnant, talk with your doctor. They’ll review the risks and benefits with you and advise whether sildenafil treatment is right for you. In certain cases, your doctor may recommend that you continue taking sildenafil during pregnancy. Sildenafil may pass into breast milk, but it isn’t known how this could affect a child who is breastfed. If you are breastfeeding or planning to breastfeed, talk with your doctor. They can review the risks and benefits of taking sildenafil while breastfeeding. If you are taking sildenafil for erectile dysfunction or pulmonary arterial hypertension, it’s possible to experience side effects.

Most side effects are mild to moderate in severity. If you’re experiencing symptoms of severe side effects while taking sildenafil, talk with your doctor right away. If you’d like to learn more about sildenafil, talk with your doctor or pharmacist.

They can help answer any questions you have about side effects from taking the drug.

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These are considered drug-condition or drug-factor interactions. The conditions and factors to consider include: If you’ve ever had PVOD, taking sildenafil can lead to heart problems. Your doctor won’t typically recommend taking sildenafil if you’ve ever had PVOD. Talk with your doctor if you develop fluid in your lungs while taking sildenafil. If you develop PVOD, your doctor will likely recommend another medication for your condition.

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If you’ve had an allergic reaction to sildenafil or any of its ingredients, your doctor will likely not prescribe sildenafil. Taking sildenafil could cause you to have another allergic reaction. Ask your doctor what other medications may be better options for you. Talk with your doctor if you’ve ever had eye disorders or if you start to experience vision loss while taking sildenafil. An eye condition called non-arteritic anterior ischemic optic neuropathy (NAION) may occur in people taking sildenafil. A generic drug and its brand-name version contain the same active ingredient, so they’re expected to have the same side effects.

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Call 911 (or your local emergency number) and go to the emergency room if you experience an erection that lasts longer than 4 hours. You may experience permanent damage to your penis if this is not treated right away. If your erections are lasting longer than usual, but less than 4 hours, talk with your doctor. They may recommend decreasing your sildenafil dosage. As with most drugs, sildenafil can cause an allergic reaction in some people.

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However, these reactions were rarely reported in clinical trials.* Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and help determine whether you should keep taking sildenafil. However, if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number. Be sure to talk with your doctor about your health history before you take sildenafil. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. Referring to the following articles about sildenafil and Viagra can provide you with additional information: For details about other aspects of sildenafil, refer to this article. To learn how sildenafil compares with Viagra, read this article. If you’d like to learn about sildenafil and cost, see this article. For details about your condition, see our hypertension hub.

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If you have sickle cell anemia, tell your doctor. You may have an increased risk of vaso-occlusive crisis (VOC) if you have sickle cell anemia and take sildenafil. With VOC, your blood cells block blood flow to your organs, which can be painful. Be sure to talk with your doctor if you have sickle cell anemia. They’ll advise if sildenafil is right for you. You can also view our men’s health hub and this list of erectile dysfunction and premature ejaculation articles.

Counseling and Sex Therapy

Nosebleeds are a common side effect of sildenafil, and they’re typically mild. In clinical trials,* people who were taking warfarin (Jantoven) had an increased risk of nosebleeds. Symptoms of nosebleeds include bleeding from one or both nostrils. It also includes feeling as if you have to swallow a lot. If you start to experience nosebleeds often or if they don’t stop, talk with your doctor.

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They may recommend applying a cold cloth to the bridge of your nose briefly or pinching your nostrils for a short period of time. Your doctor may also recommend medications to help with nosebleeds, such as oxymetazoline (Afrin). It usually happens without sexual stimulation or continues long after sex. Priapism was a rare side effect in clinical trials of sildenafil.* Priapism can become a serious side effect if your erection lasts longer than 4 hours. If you’ve ever had sickle cell anemia, multiple myeloma, or leukemia, you may have an increased risk of developing severe priapism. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Brand name Viagra® (AKA sildenafil citrate) has earned a reputation as the go-to fix for sexual challenges — especially erectile dysfunction. So, people often think of it as the magic pill for boosting stamina in bed. But can Viagra make you last longer in bed? Viagra can absolutely help you maintain an erection if that’s where you’re struggling.

And while it’s not FDA-approved specifically to treat premature ejaculation (PE), some research hints it might help you avoid early orgasm. We’ve outlined the facts on sildenafil citrate and its potential for increasing sexual stamina. Plus, we’ll introduce you to other proven ways to improve your performance in the bedroom. Some reports suggest that Viagra might be an effective treatment for premature ejaculation. Viagra (sildenafil citrate) is a type of erectile dysfunction medication called a phosphodiesterase type 5 inhibitor. PDE5 inhibitors like Viagra, Cialis® (tadalafil), and Levitra® (vardenafil) treat ED by increasing blood flow to the soft erectile tissues and blood vessels in your penis.

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So it’s unknown if sildenafil was the direct cause of these side effects. They may be due to other factors, such as preexisting heart disease, sexual activity, or a combination of these factors. Before you start sildenafil treatment, be sure to tell your doctor if you have any heart conditions. Depending on your heart health, sildenafil may not be safe for you to take. Your doctor can review the risks and benefits of taking sildenafil to determine the right treatment plan for you.

Desensitizing agents

If you’re interested in having sex while taking sildenafil for ED or PAH, talk with your doctor before starting treatment. It’s important to talk with your doctor about your heart health before having sex. Engaging in sexual activity when you have heart problems may increase your risk of severe cardiovascular problems, including heart attack. This risk may increase further if you take sildenafil, have heart problems, and have sex. Your doctor can review the risks and benefits of having sex during sildenafil treatment. Erectile dysfunction medications can help you get an erection or maintain a firmer erection to improve the sexual experience for you and your partner. On average, Viagra lasts for up to four hours after you take your dose. So, if you tend to lose your erection during sex, Viagra’s effects could help you have sex for longer.